Designer Weight-Loss Drugs on Horizon
June 10, 2002 -- An experimental drug that makes fat mice thin points the way to designer weight-loss drugs.
It's called C75. In mouse studies, it reduces appetite and makes the body burn fat faster. That's supposed to be impossible. Millions of years of evolution have hard-wired animals to save their energy during lean times. It's the bane of the eat-less diet: you burn off fat more slowly when you are losing weight. C75 somehow short-circuits this system.
Now scientists know why. And that knowledge seems likely to lead to designer drugs that can help people control their appetite while melting away stored-up fat. The new findings appear in the June 11 issue of Proceedings of the National Academy of Sciences.
"C75 is the one molecule that goes between making fat and burning it," study leader Frank Kuhajda, MD, tells WebMD. "We are mucking with the switch. Now we have an explanation of why these animals lose so much weight."
And lose weight they do. Kuhajda and colleagues at Baltimore's Johns Hopkins University saw obese mice lose 15% of their body weight after only two weeks on C75. Oh, yes, and there's one more thing about it: C75 also kills cancer cells.
But don't run out to the pharmacy looking for the drug. It's years away from any kind of human trial. Kuhajda says that even if C75 were safe in humans -- a very, very big "if" -- it isn't the right kind of drug for people.
"We can take a clue from this work to design molecules that might be drugs in the future," he says. "C75 will never be a weight-loss or cancer drug. But it is a useful tool. This work shows you how to do it."
When an animal stops eating, a kind of fatty acid builds up in the system. It's like when an assembly line shuts down. Raw materials pile up at the front end. This fatty-acid buildup signals the body to slow energy burning. C75 acts on the brain to make an animal lose its appetite. It also acts on the body to block the signals coming from fatty acids. It keeps the fat-burning machinery running at full blast.
Designer Weight-Loss Drugs on Horizon
New Compound Switches Off Appetite, Boosts Fat-Burning
June 10, 2002 -- An experimental drug that makes fat mice thin points the way to designer weight-loss drugs.
It's called C75. In mouse studies, it reduces appetite and makes the body burn fat faster. That's supposed to be impossible. Millions of years of evolution have hard-wired animals to save their energy during lean times. It's the bane of the eat-less diet: you burn off fat more slowly when you are losing weight. C75 somehow short-circuits this system.
Now scientists know why. And that knowledge seems likely to lead to designer drugs that can help people control their appetite while melting away stored-up fat. The new findings appear in the June 11 issue of Proceedings of the National Academy of Sciences.
"C75 is the one molecule that goes between making fat and burning it," study leader Frank Kuhajda, MD, tells WebMD. "We are mucking with the switch. Now we have an explanation of why these animals lose so much weight."
And lose weight they do. Kuhajda and colleagues at Baltimore's Johns Hopkins University saw obese mice lose 15% of their body weight after only two weeks on C75. Oh, yes, and there's one more thing about it: C75 also kills cancer cells.
But don't run out to the pharmacy looking for the drug. It's years away from any kind of human trial. Kuhajda says that even if C75 were safe in humans -- a very, very big "if" -- it isn't the right kind of drug for people.
"We can take a clue from this work to design molecules that might be drugs in the future," he says. "C75 will never be a weight-loss or cancer drug. But it is a useful tool. This work shows you how to do it."
When an animal stops eating, a kind of fatty acid builds up in the system. It's like when an assembly line shuts down. Raw materials pile up at the front end. This fatty-acid buildup signals the body to slow energy burning. C75 acts on the brain to make an animal lose its appetite. It also acts on the body to block the signals coming from fatty acids. It keeps the fat-burning machinery running at full blast.
Source...